Vely. In comparison with other groups, LMM-treated OCs didn’t H3 Receptor Compound present cell signaling protein expression (Figure 3). Analysis from the biological process (Figure four) shows two distinctive protein classes inside the constructive but not the adverse handle, for example biological adhesion and development. The group treated with B. moojeni crude venom presents proteins related towards the immune program (0.eight ), which also can be located inside the unfavorable manage (1 ). The group treated with HMM fraction shows an increase in the percentage of proteins connected for the immune process (two.four ) and locomotion (7.1 ). In contrast, the LMM group shows fewer proteins involved in these processes. The crude venom does not present proteins involved in the multi organism, reproduction, and reproductive approach.Toxins 2021, 13,Toxins 2021, 13, x FOR PEER REVIEW8 of8 ofFigure three. Information mAChR5 manufacturer enrichment by molecular function making use of Panther application. The graphics indicate the percentage every Figure 3. Information enrichment by molecular function employing Panther application. The graphics indicate the percentage ofof each and every approach. (A) Data enrichment graph corresponding for the constructive handle. (B) Data enrichment graph corresponding to process. (A) Information enrichment graph corresponding for the good control. (B) Data enrichment graph corresponding towards the the Adverse Control. (C) Data enrichment graph corresponding to the Bothrops moojeni crude venom. (D) Data enrichment Negativecorresponding for the low molecular mass Bothrops moojeni. (E) Information enrichment graph corresponding to the high graph Handle. (C) Data enrichment graph corresponding towards the Bothrops moojeni crude venom. (D) Information enrichment graph corresponding towards the low molecular mass Bothrops moojeni. (E) Data enrichment graph corresponding to the high molecular mass Bothrops moojeni. molecular mass Bothrops moojeni.Toxins 2021, 13,Toxins 2021, 13, x FOR PEER REVIEW9 of10 ofFigureFigure 4. enrichment by biological procedure working with Panther application. The graphics indicate the percentage ofof each four. Information Information enrichment by biological process utilizing Panther software program. The graphics indicate the percentage each method. (A) Information enrichment graph corresponding for the good control. (B) Data enrichment graph corresponding to method. (A) Data enrichment graph corresponding to the good manage. (B) Data enrichment graph corresponding to the the Adverse Handle. (C) Data enrichment graph corresponding towards the Bothrops moojeni crude venom. (D) Information enrichment Negative Manage. (C) Data for the high molecular mass Bothropsto the Bothrops moojeni crude graph corresponding towards the low graph corresponding enrichment graph corresponding moojeni. (E) Data enrichment venom. (D) Data enrichment graph molecular mass to the high molecular mass Bothrops moojeni. (E) Data enrichment graph corresponding towards the low corresponding Bothrops moojeni. molecular mass Bothrops moojeni.Toxins 2021, 13,10 ofPathway analysis (Figure five) indicates these proteins significant to OCs differentiation in the good manage group. The Hedgehog signaling pathway (P00025), histamine H1 receptor-mediated signaling pathway (P04385), and oxytocin receptor-mediated signaling pathway (P04391) are highlighted. Within the group treated with B. moojeni crude venom (Figure six), the interleukin signaling pathway (P00036), inotropic glutamate receptor pathway (P00037), metabotropic glutamate receptor group III pathway (P00039), PI3 kinase pathway (P00048), and pyrimidine metabolism (P02771) are evidenced. In t.