Product Name :
MRT00033659
Description:
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.
CAS:
1401731-54-1
Molecular Weight:
266.30
Formula:
C15H14N4O
Chemical Name:
N-(3-{3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)acetamide
Smiles :
CC1NN=C2N=CC(=CC=12)C1=CC(=CC=C1)NC(C)=O
InChiKey:
YFBPGSDPFRCNOY-UHFFFAOYSA-N
InChi :
InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Peresolimab} MedChemExpress|{Peresolimab} Immunology/Inflammation|{Peresolimab} Technical Information|{Peresolimab} In stock|{Peresolimab} supplier|{Peresolimab} Autophagy}
Shelf Life:
≥12 months if stored properly.{{TSLP Protein, Human} web|{TSLP Protein, Human} Biological Activity|{TSLP Protein, Human} In Vivo|{TSLP Protein, Human} manufacturer|{TSLP Protein, Human} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32796411
Additional information:
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.|Product information|CAS Number: 1401731-54-1|Molecular Weight: 266.30|Formula: C15H14N4O|Chemical Name: N-(3-{3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)acetamide|Smiles: CC1NN=C2N=CC(=CC=12)C1=CC(=CC=C1)NC(C)=O|InChiKey: YFBPGSDPFRCNOY-UHFFFAOYSA-N|InChi: InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (312.92 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MRT00033659 (5-40 µM; 48 hours) is sufficient to significantly reduce cell number of 5 µM. MRT00033659 (1-80 µM; 48 hours) induces substantial cell death from 5 µM. MRT00033659 (0.2-80 µM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 µM to 5 µM. MRT00033659 does not inhibit p38α MAPK.|Products are for research use only. Not for human use.|