gulant and vacuum-separated gel blood collection vessels, respectively, and stored at -80 C for subsequent testing. FPG, TC, HDL-C, LDL-C, HCY, folic acid, vitamin D2, and vitamin D3 concentrations have been measured with an Advia Clinical Chemistry Method (Siemens Healthcare, FP Agonist manufacturer Erlangen, Germany).Serum indicatorsHyperlipidemia Tumor History of fracture Nephrosis disorders Gastrointestinal CYP51 Inhibitor Synonyms issues FBG (mmol/L) HbA1C (mg/dl) TC (mmol/L)two.Statistical analysisHDL-C (mmol/L) LDL-C (mmol/L) HCY (mol/L) Folic acid (mmol/L) Vitamin D2 (mmol/L) Vitamin D3 (mmol/L)SPSS version 23 (IBM, USA) was employed to analyze all datasets. Discrete data are offered as numbers or percentages and continuous information with a standard distribution as the mean SD. To analyze possible danger aspects affecting dementia, uni- and multivariate logistic regression was employed. Data are given with 95 self-confidence intervals. The predictive potential of indicators for dementia was evaluated by receiver operating characteristic (ROC) analysis. The cutoff values for indicators were determined by ROC analyses (Youden Index). Variables with statistical significance within the univariate analysis had been combined in various approaches, to judge the diagnostic effect (ROC) of distinctive combinations. Ultimately, the optimal mixture (the largest location below the ROC curve) was suggested in accordance with the fitting efficiency of unique combination models. A statistically substantial discovering was deemed to be a two-sided p-value .05.Abbreviations: FBG, fasting blood glucose; HbA1C, hemoglobin A1C; HCY, homocysteine; HDL-C, high-density lipoprotein cholesterol; LDL-C, lowdensity lipoprotein cholesterol; TC, total cholesterol.hypertension, and cardiac issues have been the top 3 comorbidities, accounting for 74.2 , 59.five , and 38.9 , respectively (Table 1).3.2 Univariate evaluation in the common characteristics of dementia three RESULTSPatients with dementia had been significantly older than sufferers without the need of dementia, but there was no difference in gender. Respiratory issues (OR: 1.411, p .001), fractures (OR: 1.202, p .001), cardiac disorders (OR: 1.123, p .001), hypertension (OR: 1.120, p .001), A total of 4722 elderly individuals had been incorporated, with an typical age of 73.0 15.5 years, and 52.five were males. Many of the patients have been inside the Department of Neurology (77.8 ). There were 565 sufferers with dementia, with an incidence price of 12 . Cerebrovascular issues, and cerebrovascular issues (OR: 1.080, p .001) have been related having a greater risk for the incidence of dementia. Even so, diabetes did not enhance the threat of building dementia. In the perspective on the number of comorbidities, OR enhanced together with the quantity of3.1 Patient qualities and baseline information4 ofGONG ET AL .TA B L EUnivariate evaluation of gender, age, and comorbidities for dementiaDementia (n = 565) Nondementia (n = 4157) 2178 (52.four) 1979 (47.six) 71.2 15.four 3238 (77.9) 919 (22.1) 1722 (41.four) 2435 (58.six) 3853 (92.7) 304 (7.3) 4094 (98.five) 63 (1.5) 4081 (98.2) 76 (1.eight) 1120 (26.9) 3037 (73.1) 3108 (74.8) 1049 (25.two) 4147 (99.8) ten (0.2) 2678 (64.four) 1479 (35.six) 3968 (95.five) 189 (four.five) 376 (9.0) 194 (4.7) 43 (1.0) 393 (9.five) 124 (3.0) 3027 (72.8)OR (95 CI) 1.0 0.965 (0.809.151) 1.122 (1.109.135) 1.0 1.411 (1.285.549) 1.0 1.120 (1.053.192) 1.0 0.767 (0.672.875) 1.0 1.202 (1.087.329) 1.0 0.958 (0.847.082) 1.0 1.080 (1.046.116) 1.0 1.0 (0.976.026) 1.0 0.258 (0.001999.9) 1.0 1.123 (1.102.143) 1.0 0.962 (0.919.007) 1.0 7.75 (2.167.76) eight.