Thus the antiprion activity of IQ and its chemical derivatives does not parallel their agonist activity on TLR7/8. In addition, the antiprion activity of IQ against S. cerevisiae prions cannot be due to its agonist activity on TLR7 since yeast does not contain this type of receptors
After 6 times of treatment method of prioninfected MovS6 cells with a to twenty variety of focus of IQ, PrPSc was detected on the basis of its proteinase K (PK)…