e ability of cells to undergo apoptosis. Thus, experimentally increasing intracellular GSH decreases apoptosis while cells with lower GSH are more susceptible to apoptotic stimuli. Intracellular GSH levels are regulated…
loaded into both apical and basolateral chambers. After incubation at 37uC for 1 h, 5 mM digoxin was added to either apical or basolateral side to evaluate the transport in…
ases PpiA and PpiD. Accordingly, a major role of the Cpx response appears to be to maintain envelope protein folding status in the presence of adverse conditions. Molecular, biological and…
P-gp by ginsenoside Rh2 epimers in vivo, the pharmacokinetics of Rh2 epimers in vivo, the possible metabolism, and evaluation of P-gp regulatory effects in vitro were all included. Moreover, the…
opment, Wnt/bcatenin signaling often occurs in a temporal and restricted manner, and overactivation of this pathway leads to cancer development. Thus, the relative weak signal may be beneficial to prevent…
ed on lightly anesthetized mice, as described previously. A small number of animals appeared to have more severe bradycardia in response anesthesia, and these animals were not included in the…
cells: overexpression of Cx43 induces membrane location and cell proliferation decrease. J Pathol 202: 241246. 19. Teng J, Wang ZY, Prossnitz ER, Bjorling DE The G protein-coupled receptor GPR30 inhibits…
ing the fact that there was no significant difference in free Heme level between CXC102/2 infected mice and non-infected controls, we postulated that HO-1 activation may not be required under…
The between Cyclosporin A and immunosuppressive and calcineurin Microcolony Analysis of Aspergillus Discussion A. fumigatus was found to germinate, grow and produce conidia on a PAO support. Conidial germination and…
surface with imaging by fluorescence and scanning electron microscopy. Strips of PAO are highly porous but only 60 mm thick. Therefore, it is possible to add or remove compounds rapidly…