Product Name: Endothelin 3 Polyclonal Antibody, FITC Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: FITC
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human ET-3
Clonality: Polyclonal
CAS NO: 627530-84-1
Product: LY 344864
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: ET 3; ET3; ET-3; PPET3; Preproendothelin 3; Preproendothelin3; Preproendothelin-3; Endothelin3; Endothelin-3; Endothelin 3; EDN3_HUMAN.
Background: Endothelins are vasoactive proteins derived form the endothelium The active form of this protein is a 21aa peptide processed from the precursor. The active peptide binds endothelin receptor type B (EDNRB). This interaction EDNRB regulates the development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in Endothelin 3 and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20057355?dopt=Abstract