Product Name: ERCC1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 647
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human ERCC1
Clonality: Polyclonal
CAS NO: 72797-41-2
Product: INCB3344
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: UV2; COFS4; RAD1; DNA excision repair protein ERCC-1; ERCC1
Background: Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26098762?dopt=Abstract