Product Name: EPR1 Polyclonal Antibody, Cy5 Conjugated
Applications: IF(IHC-P)
Reactivity: Human
Conjugation: Cy5
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human EPR1
Clonality: Polyclonal
CAS NO: 1009298-09-2
Product: (Z)-2-decenoic acid
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: Effector cell peptidase receptor 1; Effector cell protease receptor 1; EPR 1; EPR1; EPR-1.
Background: Cellular receptors for blood proteases regulate chemotaxis, extracellular proteolysis, and growth behavior of normal and malignant cells. Effector cell protease receptor-1 (EPR1) is a receptor for the coagulation protease factor Xa. EPR1 is characterized by a cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich cytoplasmic tail featuring at least 15 potential phosphorylation sites. EPR1 also contains 2 N-linked glycosylation sites, 4 O-linked glycosylation sites, and a chondroitin sulfate attachment site, which may provide anchoring for carbohydrate chains, EPR1 transfectants bind to factor Xa in a specific and saturable manner, and in the absence of factor V/Va promote prothrombin activation in a factor Xa concentration-dependent reaction. Activated platelets and megakaryocytes express EPR1. Both EPR1 and membrane-bound factor Va are thought to be required to mediate factor Xa binding to the activated platelet to form a functional prothrombinase complex.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28426725?dopt=Abstract