Product Name: Disc1 (Frag2) Polyclonal Antibody
Applications: WB
Reactivity: Human
Conjugation: Unconjugated
Host: Rabbit
Sourcr: Recombinant human protein purified from E.coli (His-tagged)
Clonality: Polyclonal
CAS NO: 61-75-6
Product: Apocynin
Isotype: IgG
Concentration: 2ug/ul
Purification: Affinity purification
Storage: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Store for 1 year at -20°C from date of shipment.
Synonyms: SCZD9; C1orf136; Disrupted in schizophrenia 1 protein; DISC1; KIAA0457
Background: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18230058