Helicobacter pylori (H. pylori) infection remains a leading cause of chronic gastritis, peptic ulcers, and gastric adenocarcinoma worldwide. Despite advances in antibiotic-based therapies, rising resistance rates and recurrence due to…
**Background** Cancer remains a global health challenge characterized by uncontrolled cell proliferation and the evasion of apoptosis. Microtubules, essential components of the cytoskeleton, play a critical role in cell division,…
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with tobacco smoke being the primary environmental risk factor. Among the numerous carcinogens in cigarette smoke, benzo(a)pyrene (B(a)P)…
Background Host cells employ multiple intrinsic and innate antiviral mechanisms to counter human immunodeficiency virus (HIV) infection. Among these, restriction factors such as APOBEC3F/G, SamHD1, and BST2 (also known as…
**Background** Major depressive disorder is a complex psychiatric condition characterized by persistent low mood, loss of interest, and various cognitive and physical symptoms. A primary hypothesis in the pathophysiology of…
Since 2003, H5N1-subtype avian influenza viruses (AIVs) with both a deletion of 20 amino acids in the stalk of the neuraminidase (NA) glycoprotein (A2) and a deletion of five amino…
Perinatal mortality remains a pressing public health issue in northwest Nigeria, with alarming rates observed in Katsina metropolis. This study reports on the first comprehensive analysis of perinatal deaths in…
Lynch syndrome is a hereditary cancer predisposition disorder characterized by an increased risk of colorectal, endometrial, and other malignancies. It is primarily caused by germline mutations in DNA mismatch repair…
**Background** Cytomegalovirus (CMV) is a significant human pathogen that can cause severe systemic infections, particularly in immunocompromised individuals and neonates. Along with other members of the herpesvirus group, such as…
Serotonin (5-hydroxytryptamine, 5-HT) plays a crucial role in regulating vascular tone through modulation of ion channels in arterial smooth muscle cells. This study investigates the mechanism by which 5-HT induces…