Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling) 3087

Additional Information:
express systemE.coli|product tagN-His|purity> 95% as determined by Tris-Bis PAGE|backgroundPeptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.|molecular weightThe protein has a predicted MW of 76.6 kDa same as Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling) 3087proteinSize and concentration100, 500g and liquidFormLiquidStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped with dry ice.Purity> 95% as determined by Tris-Bis PAGEtarget relevancePeptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.Protein namesProtein-arginine deiminase (EC 3.5.3.15)Gene namesPADI4,PADI4Protein familyProtein arginine deiminase familyMass9541DaFunctionCatalyzes the deimination of arginine residues of proteins.Subellular locationCytoplasm .Target Relevance information above includes information from UniProt accession: A0A2K5USI5The UniProt Consortium|