Product Name: FBXO36 Polyclonal Antibody, Biotin Conjugated
Applications: IHC-P
Reactivity: Human, Mouse, Rat
Conjugation: Biotin
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human FBXO6
Clonality: Polyclonal
CAS NO: 80734-02-7
Product: Tocofersolan
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: F box only protein 36; F box protein 36; F-box only protein 36; Fbx 36; Fbx36; FBX36_HUMAN; FBXO 36; Fbxo36; FLJ37592; FLJ41090.
Background: FBXO36 is a 188 amino acid protein that contains one forty amino acid F-box region, making it a member of the F-box family. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO36 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20181954?dopt=Abstract