Product Name: FAU/MNSF-beta Polyclonal Antibody, HRP Conjugated
Applications: WB, IHC-P
Reactivity: Human, Mouse, Rat
Conjugation: HRP
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human FAU/MNSF-beta
Clonality: Polyclonal
CAS NO: 127516-23-8
Product: Nigericin (sodium salt)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Synonyms: 40S ribosomal protein S30; asr1; FAU; FAU encoded ubiquitin like protein; FAU1; FBR MuSV associated ubiquitously expressed; Finkel Biskis Reilly murine sarcoma virus FBR MuSV ubiquitously expressed fox derived; Finkel Biskis Reilly murine sarcoma virus FBR MuSV ubiquitously expressed; Finkel Biskis Reilly murine sarcoma virus ubiquitously expressed; FLJ22986; Fub1; Fubi; MNSFbeta; Monoclonal nonspecic suppressor factor beta; Ribosomal protein S30; RPS30; S30; UBIM_HUMAN; Ubiquitin like protein fubi and ribosomal protein S30; Ubiquitin like protein fubi; Ubiquitin like S30 fusion protein; Ubiquitin-like protein FUBI.
Background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. A wide range of enzymes facilitate in the proteolytic Ub pathway, including monoclonal nonspecific suppressor factor-beta (MNSF-beta), a subunit of MNSF, which is a lymphokine product of a murine T cell hybrid-oma that restricts the production of LPS-induced immunoglobulin secreting cells in an antigen-nonspecific manner. MNSF-beta is a ubiquitin-like fusion protein consisting of the ribosomal protein S30 and a protein that shares 36% sequence identity with ubiquitin. This ubiquitin-like segment (Ubi-L) can be cleaved from MNSF-beta in the cytosol.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23436750?dopt=Abstract