Product Name: Deformed Epidermal Autoregulatory Factor 1 Antibody, Biotin Conjugated
Applications: WB, IHC-P
Reactivity: Mouse, Rat
Conjugation: Biotin
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Deformed Epidermal Autoregulatory Factor 1
Clonality: Polyclonal
CAS NO: 404950-80-7
product targets : Ribosomal S6 Kinase (RSK) inhibitors
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: DEAF1; Deformed epidermal autoregulatory factor 1 homolog; Nuclear DEA1 related transcriptional regulator; NUDR; SPN; Suppressin; Zinc finger MYND domain containing protein 5; ZMYND5; DEAF1_HUMAN.
Background: Suppressin, also known as DEAF1 is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22405837